Purpose: to evaluate and compare histogram feature, such as mean lung attenuation (MLA), skewness and kurtosis, of low-dose and standard dose in a group of patient affected by idiopathic interstitial pneumonitis. Methods: we prospectively examined 16 patients affected by idiopathic interstitial pneumonitis and 4 healthy volunteers. Spiral whole lung thin-section CT examination at standard current (100 mAs) and sequential 3 slice thin section CT acquisitions at low-dose (50 mAs) were obtained for all patients. For each patient, one pair of corresponding images obtained by the standard and low-dose examination at the same anatomical level were chosen and analyzed. After obtained frequency histograms, MLA, skewness, kurtosis and 3 range of density (-700/-200 HU; -700/-400 HU; -500/-200 HU) of the standard and low-dose thin section CT scans were calculated and compared using Student’s “t” test, Pearson correlation coefficients and Bland-Altman test. Results: it was found that the histograms of pathologic subjects were significantly different from the healthy subject’s one (p<0,01). We found that there was no significant difference between patients affected by idiopathic pulmonary fibrosis (IPF) and patients affected by other kinds of idiopathic interstitial pneumonitis (p>0,5). However, the parameters obtained with low-dose and standard dose spiral CT were correlated in a highly significant manner and are equivalent (p<0,01). Conclusions: Our results prove that a quantitative CT evaluation in lung fibrosis can be successfully obtained with low-dose spiral CT, with reduced current.

Evaluation of Frequency Histograms and Ranges of Density in Idiopathic Interstitial Pneumonitis Using 50% Reduced-dose Thin Section CT / N. Sverzellati; R. Cobelli; G. De Luca; C.R. Bna`; M. Zompatori. - In: JOURNAL OF THORACIC IMAGING. - ISSN 0883-5993. - 20:2(2005), p. 164.

Evaluation of Frequency Histograms and Ranges of Density in Idiopathic Interstitial Pneumonitis Using 50% Reduced-dose Thin Section CT

SVERZELLATI, Nicola;
2005

Abstract

Purpose: to evaluate and compare histogram feature, such as mean lung attenuation (MLA), skewness and kurtosis, of low-dose and standard dose in a group of patient affected by idiopathic interstitial pneumonitis. Methods: we prospectively examined 16 patients affected by idiopathic interstitial pneumonitis and 4 healthy volunteers. Spiral whole lung thin-section CT examination at standard current (100 mAs) and sequential 3 slice thin section CT acquisitions at low-dose (50 mAs) were obtained for all patients. For each patient, one pair of corresponding images obtained by the standard and low-dose examination at the same anatomical level were chosen and analyzed. After obtained frequency histograms, MLA, skewness, kurtosis and 3 range of density (-700/-200 HU; -700/-400 HU; -500/-200 HU) of the standard and low-dose thin section CT scans were calculated and compared using Student’s “t” test, Pearson correlation coefficients and Bland-Altman test. Results: it was found that the histograms of pathologic subjects were significantly different from the healthy subject’s one (p<0,01). We found that there was no significant difference between patients affected by idiopathic pulmonary fibrosis (IPF) and patients affected by other kinds of idiopathic interstitial pneumonitis (p>0,5). However, the parameters obtained with low-dose and standard dose spiral CT were correlated in a highly significant manner and are equivalent (p<0,01). Conclusions: Our results prove that a quantitative CT evaluation in lung fibrosis can be successfully obtained with low-dose spiral CT, with reduced current.
Evaluation of Frequency Histograms and Ranges of Density in Idiopathic Interstitial Pneumonitis Using 50% Reduced-dose Thin Section CT / N. Sverzellati; R. Cobelli; G. De Luca; C.R. Bna`; M. Zompatori. - In: JOURNAL OF THORACIC IMAGING. - ISSN 0883-5993. - 20:2(2005), p. 164.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2536073
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