The expression of CR3 by murine-resting epidermal Langerhans cells (LC) is well established but CR3 expression by human normal-resting epidermal LC has not yet been demonstrated. In this study. highly sensitive immunostaining techniques, such as immunogold labelling in transmission- and scanning-electron microscopy, were used on freshly isolated, LC-enriched, normal human epidermal cells. Human normal resting epidermal LC were found to be CR3+, since a low but significant number of gold granules labelled the plasma membrane of all the LC observed under transmission-electron microscopy, and all the epidermal cells showìng LC morphology as observed by scanning-elecrron microscopy
Human normal resting Langerhans' cells do express the type 3 complement receptor (CR3) / DE PANFILIS, Giuseppe; Soligo, D.; Manara, Giancarlo; Ferrari, Corrado; Torresani, Claudio; Zucchi, Alfredo. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 0007-0963. - 122:(1990), pp. 127-136.
Human normal resting Langerhans' cells do express the type 3 complement receptor (CR3).
DE PANFILIS, Giuseppe;MANARA, Giancarlo;FERRARI, Corrado;TORRESANI, Claudio;ZUCCHI, Alfredo
1990-01-01
Abstract
The expression of CR3 by murine-resting epidermal Langerhans cells (LC) is well established but CR3 expression by human normal-resting epidermal LC has not yet been demonstrated. In this study. highly sensitive immunostaining techniques, such as immunogold labelling in transmission- and scanning-electron microscopy, were used on freshly isolated, LC-enriched, normal human epidermal cells. Human normal resting epidermal LC were found to be CR3+, since a low but significant number of gold granules labelled the plasma membrane of all the LC observed under transmission-electron microscopy, and all the epidermal cells showìng LC morphology as observed by scanning-elecrron microscopy| File | Dimensione | Formato | |
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