Abstract X-ray diffraction has long been employed in mineralogy to examine the structure and composition of crystals. Its application to renal and biliary calculi enables their crystalline structure to be analysed, and its components rapidly and reliably identified. It also permits the detection of formation nuclei or successive growth stages, whereas conventional chemical analysis gives a precise picture of the composition of a calculus in only 50% of cases. Results obtained with X-ray crystallography in urinary lithiasis are presented. Calcium oxalate calculi appear typically in healthy subjects with no detectable clinical chemical changes, while struvite (MgNH 4PO 4) stones are closely associated with infection and pure apatite [Ca 10(PO 4) 6(OH) 2] with hyperparathyroidism. The correspondence between composition and basic disease suggests that different pathogenetic mechanisms are at work. X-ray crystallography is a method that is of great clinical interest in the analysis of calculi, and in research directed to the study of their natural history and intrinsic pathogenesis.
X-ray crystallography in the study of urinary lithiasis.Methodological features and clinical results / G., Bruschi; A., Recusani; Coruzzi, Paolo; Biggi, Almerina; A., Novarini; A., Borghetti. - In: MINERVA NEFROLOGICA. - ISSN 0026-4873. - 26:3(1979), pp. 333-337.
X-ray crystallography in the study of urinary lithiasis.Methodological features and clinical results
CORUZZI, Paolo;BIGGI, Almerina;
1979-01-01
Abstract
Abstract X-ray diffraction has long been employed in mineralogy to examine the structure and composition of crystals. Its application to renal and biliary calculi enables their crystalline structure to be analysed, and its components rapidly and reliably identified. It also permits the detection of formation nuclei or successive growth stages, whereas conventional chemical analysis gives a precise picture of the composition of a calculus in only 50% of cases. Results obtained with X-ray crystallography in urinary lithiasis are presented. Calcium oxalate calculi appear typically in healthy subjects with no detectable clinical chemical changes, while struvite (MgNH 4PO 4) stones are closely associated with infection and pure apatite [Ca 10(PO 4) 6(OH) 2] with hyperparathyroidism. The correspondence between composition and basic disease suggests that different pathogenetic mechanisms are at work. X-ray crystallography is a method that is of great clinical interest in the analysis of calculi, and in research directed to the study of their natural history and intrinsic pathogenesis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
