PURPOSE: The authors assessed the clinical usefulness of high-resolution computed tomography (HRCT) for monitoring sarcoidosis by comparing changes on HRCT with those on pulmonary function test (PFT) results over time. MATERIALS AND METHODS: The baseline and follow-up (after 13 months, range 15-63 months) HRCT scans of 14 consecutive patients with sarcoidosis were reviewed by a single observer. Each follow-up HRCT examination was assessed as stable, improved (when the extent of HRCT findings was reduced compared with baseline) and worsened (when the extent of HRCT findings was increased and/or when HRCT pattern had become fibrotic compared with baseline). Any increase or decrease in forced vital capacity (FVC)≥10% from baseline was considered significant. Changes on HRCT were then compared with those on FVC. RESULTS: During a median follow-up of 33 (range 15-63) months, HRCT findings worsened in 8/14 (58%) cases, improved in 3/14 (21%) and remained stable in 3/14 (21%). Agreement between changes on HRCT and FVC was moderate (κ=0.49). In 9/14 (64%) cases, HRCT changes were in line with those on FVC. In 4/5 discordant cases, the worsened HRCT findings were not mirrored by FVC changes. CONCLUSIONS: Despite the small size of our study population, our results suggest that HRCT may provide clinicians with additional information about the evolution of sarcoidosis.

Follow-up in pulmonary sarcoidosis: comparison between HRCT and pulmonary function tests / Gafà, Giuseppe; Sverzellati, Nicola; Bonati, Elisa; Chetta, Alfredo Antonio; Franco, Fabio; Rabaiotti, Enrico; DE FILIPPO, Massimo; Marangio, Emilio; Figoli, Davide; Meschi, Tiziana; Zompatori, Maurizio; Rossi, Cristina. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 117:(2012), pp. 968-978. [10.1007/s11547-012-0827-5]

Follow-up in pulmonary sarcoidosis: comparison between HRCT and pulmonary function tests

SVERZELLATI, Nicola;CHETTA, Alfredo Antonio;DE FILIPPO, Massimo;MARANGIO, Emilio;MESCHI, Tiziana;ROSSI, Cristina
2012-01-01

Abstract

PURPOSE: The authors assessed the clinical usefulness of high-resolution computed tomography (HRCT) for monitoring sarcoidosis by comparing changes on HRCT with those on pulmonary function test (PFT) results over time. MATERIALS AND METHODS: The baseline and follow-up (after 13 months, range 15-63 months) HRCT scans of 14 consecutive patients with sarcoidosis were reviewed by a single observer. Each follow-up HRCT examination was assessed as stable, improved (when the extent of HRCT findings was reduced compared with baseline) and worsened (when the extent of HRCT findings was increased and/or when HRCT pattern had become fibrotic compared with baseline). Any increase or decrease in forced vital capacity (FVC)≥10% from baseline was considered significant. Changes on HRCT were then compared with those on FVC. RESULTS: During a median follow-up of 33 (range 15-63) months, HRCT findings worsened in 8/14 (58%) cases, improved in 3/14 (21%) and remained stable in 3/14 (21%). Agreement between changes on HRCT and FVC was moderate (κ=0.49). In 9/14 (64%) cases, HRCT changes were in line with those on FVC. In 4/5 discordant cases, the worsened HRCT findings were not mirrored by FVC changes. CONCLUSIONS: Despite the small size of our study population, our results suggest that HRCT may provide clinicians with additional information about the evolution of sarcoidosis.
2012
Follow-up in pulmonary sarcoidosis: comparison between HRCT and pulmonary function tests / Gafà, Giuseppe; Sverzellati, Nicola; Bonati, Elisa; Chetta, Alfredo Antonio; Franco, Fabio; Rabaiotti, Enrico; DE FILIPPO, Massimo; Marangio, Emilio; Figoli, Davide; Meschi, Tiziana; Zompatori, Maurizio; Rossi, Cristina. - In: LA RADIOLOGIA MEDICA. - ISSN 0033-8362. - 117:(2012), pp. 968-978. [10.1007/s11547-012-0827-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2524654
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