Intravenous administration of caerulein (40 ng/kg) delayed gastric emptying of solids in man. Radiological examinations demonstrated that the peptide causes a marked contraction of the pyloric sphincter and a relaxation of the gastric corpus and fundus. Therefore the effect of caerulein on gastric emptying may be considered as the result of different actions on the distal and proximal stomach. Furthermore pretreatment of the subjects with cimetidine did not modify the effect of caerulein indicating an action independent of the gastric hypersecretory effect of the peptide. The action of caerulein on gastric emptying must be kept in mind when the peptide is employed in the treatment of some pathological conditions.
Caerulein delays gastric emptying of solids in man / Scarpignato, Carmelo; Zimbaro, G; Vitulo, F; Bertaccini, G.. - In: ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE. - ISSN 0003-9780. - 249:1(1981), pp. 98-105.
Caerulein delays gastric emptying of solids in man.
SCARPIGNATO, Carmelo;
1981-01-01
Abstract
Intravenous administration of caerulein (40 ng/kg) delayed gastric emptying of solids in man. Radiological examinations demonstrated that the peptide causes a marked contraction of the pyloric sphincter and a relaxation of the gastric corpus and fundus. Therefore the effect of caerulein on gastric emptying may be considered as the result of different actions on the distal and proximal stomach. Furthermore pretreatment of the subjects with cimetidine did not modify the effect of caerulein indicating an action independent of the gastric hypersecretory effect of the peptide. The action of caerulein on gastric emptying must be kept in mind when the peptide is employed in the treatment of some pathological conditions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
