Cimetidine, which strongly stimulates prolactin release in healthy man, was unable to modify prolactin levels in prolactin-secreting pituitary adenomas. Furthermore, the infusion of 5-methylhistamine, an H2-receptor selective agonist, was equally ineffective. The results of these experiments together with the data reported in the literature suggest that H2-receptors modulate prolactin secretion at a hypothalamic level.
Failure of drugs acting on H2-receptors to modify plasma prolactin levels in pituitary adenomas: evidence for a suprapituitary locus of action / Scarpignato, Carmelo; Valenti, G; Ceda, Gian Paolo; Bertaccini, G.. - In: INTERNATIONAL PHARMACOPSYCHIATRY. - ISSN 0020-8272. - 16:2(1981), pp. 79-83.
Failure of drugs acting on H2-receptors to modify plasma prolactin levels in pituitary adenomas: evidence for a suprapituitary locus of action.
SCARPIGNATO, Carmelo;CEDA, Gian Paolo;
1981-01-01
Abstract
Cimetidine, which strongly stimulates prolactin release in healthy man, was unable to modify prolactin levels in prolactin-secreting pituitary adenomas. Furthermore, the infusion of 5-methylhistamine, an H2-receptor selective agonist, was equally ineffective. The results of these experiments together with the data reported in the literature suggest that H2-receptors modulate prolactin secretion at a hypothalamic level.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.