1 Substance P and its natural analogues were tested for their effect on gastric emptying in the rat. 2 Substance P and kassinin were virtually inactive even at the maximum dose tests. 3 The other tachykinins significantly delayed gastric emptying their effect being quite remarkable with 100 micrograms/kg. The lowest doses (30 microgram/kg) caused a slight and non-significant increase in emptying rate. 4 The effect on gastric emptying was most probably correlated with a spasmogenic effect on the gastroduodenal junction, as pointed out in previous work.
Effect of substance P and its natural analogues on gastric emptying of the conscious rat / Bertaccini G;de Castiglione R;Scarpignato C. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 72:2(1981), pp. 221-223.
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