The effect of the H2-receptor antagonist ranitidine on pancreatic exocrine secretion was studied in the rat. In anaesthetized animals with acute fistulas pancreatic secretion was induced by central (2-deoxy-D-glucose, 2-DG) or peripheral (acetylcholine) cholinergic stimulants and by cholecystokinin and secretin. In some experiments cimetidine was used as a reference compound. Ranitidine (20 mg X kg-1 intraperitoneally) did not change neither basal secretion nor the response to the combined hormonal stimulation. On the contrary, it significantly increased 2-DG and acetylcholine-stimulated secretion, whereas cimetidine (100 mg X kg-1 intraperitoneally) inhibited the pancreatic response to 2-DG. The different behaviour of the two H2-antagonists suggests that the effect of ranitidine is independent of the H2-receptor blockade and most probably connected with the cholinergic-like action of the drug.

The effect of ranitidine on exocrine pancreatic secretion in the rat / Chariot, J; Rozé, C; Scarpignato, Carmelo. - In: ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE. - ISSN 0003-9780. - 274:1(1985), pp. 166-176.

The effect of ranitidine on exocrine pancreatic secretion in the rat.

SCARPIGNATO, Carmelo
1985-01-01

Abstract

The effect of the H2-receptor antagonist ranitidine on pancreatic exocrine secretion was studied in the rat. In anaesthetized animals with acute fistulas pancreatic secretion was induced by central (2-deoxy-D-glucose, 2-DG) or peripheral (acetylcholine) cholinergic stimulants and by cholecystokinin and secretin. In some experiments cimetidine was used as a reference compound. Ranitidine (20 mg X kg-1 intraperitoneally) did not change neither basal secretion nor the response to the combined hormonal stimulation. On the contrary, it significantly increased 2-DG and acetylcholine-stimulated secretion, whereas cimetidine (100 mg X kg-1 intraperitoneally) inhibited the pancreatic response to 2-DG. The different behaviour of the two H2-antagonists suggests that the effect of ranitidine is independent of the H2-receptor blockade and most probably connected with the cholinergic-like action of the drug.
1985
The effect of ranitidine on exocrine pancreatic secretion in the rat / Chariot, J; Rozé, C; Scarpignato, Carmelo. - In: ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE. - ISSN 0003-9780. - 274:1(1985), pp. 166-176.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2520567
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