Intraperitoneal, but not intravenous administration of dimaprit (50-125 mg/kg) caused a dose-dependent writhing in the rat. This effect was blocked, again in a dose-dependent fashion, by cimetidine administered orally 1 h prior to dimaprit. Results obtained suggest that dimaprit induces a cimetidine-sensitive pain by acting at peripheral nociceptive terminals within the peritoneum. The specific (H2-receptor related) analgesic effect of cimetidine could explain its effectiveness in relieving epigastric pain of duodenal ulcer patients treated with the drug.
Cimetidine inhibition of dimaprit-induced writhing in the rat / Scarpignato, Carmelo; Del Soldato, P.. - In: PHARMACOLOGY. - ISSN 0031-7012. - 32:4(1986), pp. 237-240.
Cimetidine inhibition of dimaprit-induced writhing in the rat.
SCARPIGNATO, Carmelo;
1986-01-01
Abstract
Intraperitoneal, but not intravenous administration of dimaprit (50-125 mg/kg) caused a dose-dependent writhing in the rat. This effect was blocked, again in a dose-dependent fashion, by cimetidine administered orally 1 h prior to dimaprit. Results obtained suggest that dimaprit induces a cimetidine-sensitive pain by acting at peripheral nociceptive terminals within the peritoneum. The specific (H2-receptor related) analgesic effect of cimetidine could explain its effectiveness in relieving epigastric pain of duodenal ulcer patients treated with the drug.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
