Objective – Little is known on the impact of HDL athero-protective properties on vascular remodeling in healthy subjects. We investigated the relationship between serum cholesterol efflux capacity, an indicator of HDL functionality, and Pulse Wave Velocity (PWV), an indicator of arterial stiffness, in healthy subjects. Methods and Results - 151 healthy subjects (45 males, 106 females) underwent serum cholesterol efflux capacity measurement (aqueous diffusion and ATP binding cassette A1 (ABCA1)-dependent cholesterol efflux) and carotid-femoral PWV with a high-fidelity tonometer. In the unadjusted model, PWV relates directly with aqueous cholesterol diffusion (R2= 0.021, P= 0.039) and indirectly with ABCA1-dependent cholesterol efflux (R2= 0.045, P= 0.009). In a stepwise multivariate analysis including age, body mass index, mean arterial pressure, serum low density lipoprotein and HDL levels, fasting plasma glucose, ABCA1-dependent cholesterol efflux, and aqueous cholesterol diffusion, the best PWV predictors were mean arterial pressure (B= 0.66, 95%CI 0.048-0,085), age (B= 0.039, 95%CI 0.022-0.055) and ABCA1-dependent cholesterol efflux (B= -0.232, 95%CI -0.405--0.059). Conclusions – The finding that ABCA1-dependent cholesterol efflux capacity, but not serum HDL levels, is a significant predictor of PWV in healthy subjects points to the relevance of HDL function in vascular modeling and arterial stiffness prevention along life.

SERUM CHOLESTEROL EFFLUX CAPACITY INVERSELY CORRELATES WITH ARTERIAL STIFFNESS IN HEALTHY SUBJECTS / E. Favari; A. F.G. Cicero; N. Ronda; M. P. Adorni; F. Zimetti; P. Salvi; C. Borghi; F Bernini. - STAMPA. - (2012), pp. 71-71. ((Intervento presentato al convegno 35th annual conference European Lipoprotein Club (ELC) tenutosi a Tutzing (Germania) nel 10-13 Settembre 2012.

SERUM CHOLESTEROL EFFLUX CAPACITY INVERSELY CORRELATES WITH ARTERIAL STIFFNESS IN HEALTHY SUBJECTS

FAVARI, Elda;RONDA, Nicoletta;ADORNI, Maria Pia;ZIMETTI, Francesca;BERNINI, Franco
2012

Abstract

Objective – Little is known on the impact of HDL athero-protective properties on vascular remodeling in healthy subjects. We investigated the relationship between serum cholesterol efflux capacity, an indicator of HDL functionality, and Pulse Wave Velocity (PWV), an indicator of arterial stiffness, in healthy subjects. Methods and Results - 151 healthy subjects (45 males, 106 females) underwent serum cholesterol efflux capacity measurement (aqueous diffusion and ATP binding cassette A1 (ABCA1)-dependent cholesterol efflux) and carotid-femoral PWV with a high-fidelity tonometer. In the unadjusted model, PWV relates directly with aqueous cholesterol diffusion (R2= 0.021, P= 0.039) and indirectly with ABCA1-dependent cholesterol efflux (R2= 0.045, P= 0.009). In a stepwise multivariate analysis including age, body mass index, mean arterial pressure, serum low density lipoprotein and HDL levels, fasting plasma glucose, ABCA1-dependent cholesterol efflux, and aqueous cholesterol diffusion, the best PWV predictors were mean arterial pressure (B= 0.66, 95%CI 0.048-0,085), age (B= 0.039, 95%CI 0.022-0.055) and ABCA1-dependent cholesterol efflux (B= -0.232, 95%CI -0.405--0.059). Conclusions – The finding that ABCA1-dependent cholesterol efflux capacity, but not serum HDL levels, is a significant predictor of PWV in healthy subjects points to the relevance of HDL function in vascular modeling and arterial stiffness prevention along life.
SERUM CHOLESTEROL EFFLUX CAPACITY INVERSELY CORRELATES WITH ARTERIAL STIFFNESS IN HEALTHY SUBJECTS / E. Favari; A. F.G. Cicero; N. Ronda; M. P. Adorni; F. Zimetti; P. Salvi; C. Borghi; F Bernini. - STAMPA. - (2012), pp. 71-71. ((Intervento presentato al convegno 35th annual conference European Lipoprotein Club (ELC) tenutosi a Tutzing (Germania) nel 10-13 Settembre 2012.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2509845
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact