The term latent coeliac disease applies to patients who have a normal jejunal biopsy while taking a normal diet and, at some other time, before or since, have had a flat jejunal biopsy recovering on a gluten-free diet. Nineteen such patients were identified after a multicentre search conducted under the auspices of the Italian Society for Paediatric Gastroenterology and Hepatology (SIGEP). Serological data and histological material suitable for morphometric analysis were available from 10 and 8 patients, respectively, while they were on a gluten-containing diet. Neither gliadin antibodies nor increased density of intraepithelial lymphocytes are obligate markers of latent coeliac disease; endomysial antibodies are likely to be best predictors of evolution towards villous atrophy. Prospective studies are needed to allow a more precise definition of latent coeliac patient features.

Latent coeliac disease in Italy / Troncone, R.; Catassi, C.; Lambertini, A.; Zaniboni, M. G.; Lazzari, R.; Bottaro, G.; Magazzu', G.; D'Addezio, M.; Mayer, M.; Mugione, P.; Guariso, G.; Cataldo, F.; DE ANGELIS, Gian Luigi; Bonamico, M.; Barbato, M.; Ventura, A.. - In: ACTA PAEDIATRICA. - ISSN 0803-5253. - 84:11(1995), pp. 1252-1257.

Latent coeliac disease in Italy

DE ANGELIS, Gian Luigi;
1995-01-01

Abstract

The term latent coeliac disease applies to patients who have a normal jejunal biopsy while taking a normal diet and, at some other time, before or since, have had a flat jejunal biopsy recovering on a gluten-free diet. Nineteen such patients were identified after a multicentre search conducted under the auspices of the Italian Society for Paediatric Gastroenterology and Hepatology (SIGEP). Serological data and histological material suitable for morphometric analysis were available from 10 and 8 patients, respectively, while they were on a gluten-containing diet. Neither gliadin antibodies nor increased density of intraepithelial lymphocytes are obligate markers of latent coeliac disease; endomysial antibodies are likely to be best predictors of evolution towards villous atrophy. Prospective studies are needed to allow a more precise definition of latent coeliac patient features.
1995
Latent coeliac disease in Italy / Troncone, R.; Catassi, C.; Lambertini, A.; Zaniboni, M. G.; Lazzari, R.; Bottaro, G.; Magazzu', G.; D'Addezio, M.; Mayer, M.; Mugione, P.; Guariso, G.; Cataldo, F.; DE ANGELIS, Gian Luigi; Bonamico, M.; Barbato, M.; Ventura, A.. - In: ACTA PAEDIATRICA. - ISSN 0803-5253. - 84:11(1995), pp. 1252-1257.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2492836
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