RBV is effective in vitro against flaviviruses responsible for encephalitis. Its efficacy at central level is hindered by bloodbrain barrier leading to low intracerebral concentrations. The aim of this work was to assess transport and distribution of ribavirin (RBV) in central nervous system after intranasal administration of an aqueous solution of the drug.
Nose-to-brain delivery of ribavirin (RBV) for the treatment of viral encephalitis / V., Galligioni; A., Scagliarini; L., Lorenzini; A., Giuliani; E., Zironi; G., Pagliuca; L., Calzà; Colombo, Paolo; Sonvico, Fabio; E., Menegatti; Colombo, Gaia. - In: THE AAPS JOURNAL. - ISSN 1550-7416. - 12(S2):(2010), pp. M1067-M1067. (Intervento presentato al convegno 2010 AAPS Annual Meeting tenutosi a New Orleans (USA) nel November 14-18, 2010).
Nose-to-brain delivery of ribavirin (RBV) for the treatment of viral encephalitis
COLOMBO, Paolo;SONVICO, Fabio;COLOMBO, GAIA
2010-01-01
Abstract
RBV is effective in vitro against flaviviruses responsible for encephalitis. Its efficacy at central level is hindered by bloodbrain barrier leading to low intracerebral concentrations. The aim of this work was to assess transport and distribution of ribavirin (RBV) in central nervous system after intranasal administration of an aqueous solution of the drug.| File | Dimensione | Formato | |
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