The dexamethasone suppression test (DST) was administered in 48 daily chronic headache (DCH) sufferers, 37 of whom also suffered from mild to severe depression. In 14 of 48 subjects (29.2\%), cortisol values at 1600h were greater than 50 ng/ml, despite normal suppression at 0800h. The escapers showed basal cortisol values and (Depression scale) scores on the Minnesota Multiphasic Personality Inventory higher than suppressors. Thus, a group of DCH sufferers appeared to share a biochemical defect often seen in endogenous depression. The escape from dexamethasone suppression could be a psychobiological indicator of vulnerability to develop depressive disorder and/or chronic pain complaints.
Abnormal dexamethasone suppression test in daily chronic headache sufferers / E. Martignoni;F. Facchinetti;G. C. Manzoni;F. Petraglia;G. Nappi;A. R. Genazzani. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - 19(1986), pp. 51-57.
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