AIMS: This study was aimed for evaluation of Italian students' attitudes to addictive substances, their knowledge and personal experience, and their awareness about the risks. METHODS: The research was realized among high school students from Marche region in the Central Italy in the year 2006; the study group was randomly chosen from all schools in the region. 4118 appropriately completed questionnaires returned. The statistic processing was carried out by using chi-square test for two qualitative variables.
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