Administration of pyridoxine-alpha-ketoglutarate (PAK) to a group of insulin-independent non-ketotic diabetics decreased (p less than 0.01) the plasma concentration of lactate response to isometric exercise. The mechanism of action of PAK could be interpreted as a consequence of changes induced by the drug on the Krebs' cycle with a subsequent reduction of lactate production.
The effect of pyridoxine-alpha-ketoglutarate (PAK) on exercise-induced increase of blood lactate in patients with type I diabetes / Dall'Aglio E; Zavaroni I; Alpi O; Coscelli C; Butturini U.. - In: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY THERAPY AND TOXICOLOGY. - ISSN 0174-4879. - 20(3)(1982), pp. 147-150.
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