Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents
Peptides of the Constant Region of Antibodies Display Fungicidal Activity / Polonelli, Luciano; Ciociola, Tecla; Magliani, Valter; Zanello, Pier Paolo; D'Adda, Tiziana; Galati, Serena; F., De Bernardis; S., Arancia; E., Gabrielli; E., Pericolini; A., Vecchiarelli; D. C., Arruda; M. R., Pinto; L. R., Travassos; Pertinhez, Thelma; Spisni, Alberto; Conti, Stefania. - In: PLOS ONE. - ISSN 1932-6203. - 7:(2012), p. e34105. [10.1371/journal.pone.0034105]
Peptides of the Constant Region of Antibodies Display Fungicidal Activity
POLONELLI, Luciano;CIOCIOLA, Tecla;MAGLIANI, Valter;ZANELLO, Pier Paolo;D'ADDA, Tiziana;GALATI, Serena;PERTINHEZ, Thelma;SPISNI, Alberto;CONTI, Stefania
2012-01-01
Abstract
Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agentsFile | Dimensione | Formato | |
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