Two series of experiments were performed on rat chronic ulcer in order to assess the possible curative and mucosal protective properties of 2 week treatments, or the preventive properties of 4 week treatments with antisecretory agents, acting with different mechanisms of action. At the end of the treatments the gastric secretory and motor responsiveness to a gastrin-like stimulus was simultaneously evaluated. The results support the view that antimuscarinic agents as well as H2-blockers cannot be defined as protective and that after a 4 week treatment they can induce modifications of gastric functions.
Effects of antimuscarinic agents, H2-blockers and omeprazole on rat chronic gastric ulcer after long-a and short-term administration / Chiavarini, Milena; Morini, Giuseppina; Barocelli, Elisabetta; Impicciatore, Mariannina; Bordi, Fabrizio. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 43:(1988), pp. 479-487.
Effects of antimuscarinic agents, H2-blockers and omeprazole on rat chronic gastric ulcer after long-a and short-term administration
CHIAVARINI, Milena;MORINI, Giuseppina;BAROCELLI, Elisabetta;IMPICCIATORE, Mariannina;BORDI, Fabrizio
1988-01-01
Abstract
Two series of experiments were performed on rat chronic ulcer in order to assess the possible curative and mucosal protective properties of 2 week treatments, or the preventive properties of 4 week treatments with antisecretory agents, acting with different mechanisms of action. At the end of the treatments the gastric secretory and motor responsiveness to a gastrin-like stimulus was simultaneously evaluated. The results support the view that antimuscarinic agents as well as H2-blockers cannot be defined as protective and that after a 4 week treatment they can induce modifications of gastric functions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
