Sprague-Dawley male rats from the Ivanovas-Sieve colony (IVA-SIV) show higher plasma triglyceride levels compared to the standard Charles River (CR) rats. The triglyceride enrichment occurs primarily in the very-low-density lipoproteins (VLDL), otherwise of a normal % composition, suggesting that the number of particles is increased, rather than their triglyceride (TG) content. High-density lipoprotein (HDL) particles, corresponding to HDL1, appear to be increased in the IVA-SIV rats, as confirmed by rate-zonal ultracentrifugation. The apoprotein composition of isolated lipoproteins (apo B content and isoelectric focusing pattern), does not differ in the two strains. The IVA-SIV rats are remarkably more TG inducible, compared to the standard CR. This can be shown with fructose loading and with a cholesterol-cholic acid diet. The plasma TG increase, after Triton administration, indicative of the VLDL-TG production, is fourfold higher in the IVA-SIV, compared to the CR rats. These findings provide evidence for some similarities between the IVA-SIV rat and human endogenous hypertriglyceridemia, and suggest an increased TG biosynthesis in this model.

Endogenous hypertriglyceridemia in a nonobese rat model: plasma lipoproteins and dietary sensitivity / Lovati, Mr; Franceschini, G; Allievi, L; Dall'Aglio, Elisabetta; Zavaroni, Ivana; Sirtori, Cr. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - 35 (5):(1986), pp. 436-440.

Endogenous hypertriglyceridemia in a nonobese rat model: plasma lipoproteins and dietary sensitivity.

DALL'AGLIO, Elisabetta;ZAVARONI, Ivana;
1986-01-01

Abstract

Sprague-Dawley male rats from the Ivanovas-Sieve colony (IVA-SIV) show higher plasma triglyceride levels compared to the standard Charles River (CR) rats. The triglyceride enrichment occurs primarily in the very-low-density lipoproteins (VLDL), otherwise of a normal % composition, suggesting that the number of particles is increased, rather than their triglyceride (TG) content. High-density lipoprotein (HDL) particles, corresponding to HDL1, appear to be increased in the IVA-SIV rats, as confirmed by rate-zonal ultracentrifugation. The apoprotein composition of isolated lipoproteins (apo B content and isoelectric focusing pattern), does not differ in the two strains. The IVA-SIV rats are remarkably more TG inducible, compared to the standard CR. This can be shown with fructose loading and with a cholesterol-cholic acid diet. The plasma TG increase, after Triton administration, indicative of the VLDL-TG production, is fourfold higher in the IVA-SIV, compared to the CR rats. These findings provide evidence for some similarities between the IVA-SIV rat and human endogenous hypertriglyceridemia, and suggest an increased TG biosynthesis in this model.
1986
Endogenous hypertriglyceridemia in a nonobese rat model: plasma lipoproteins and dietary sensitivity / Lovati, Mr; Franceschini, G; Allievi, L; Dall'Aglio, Elisabetta; Zavaroni, Ivana; Sirtori, Cr. - In: METABOLISM, CLINICAL AND EXPERIMENTAL. - ISSN 0026-0495. - 35 (5):(1986), pp. 436-440.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2434151
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