Thirty-one children with bacterial diarrhoea were administered an oral suspension of rifaximin (14 children, mean age: 4.3 yrs; dosage: 5 ml, equal to 100 mg, x 4/day for 3 days on average) or of neomycin+bacitracin (17 children, mean age: 3.6 yrs; dosage: 5 ml x 4/day for 4 days on average). Etiologic agents were: minor Salmonella spp in 9 and 7 cases respectively; enteropathogenic E. coli in 5 and 10 cases. Rifaximin yielded bacteriological cure in 12/14 children; the reference drug in 13/17. With both antibiotics, stool number/day fell, after one day, from 6 on average, to normality (2-3 stools); within two days stool consistency and characteristics shifted to normal. Symptomatology was quickly eliminated in all of the cured children. Both treatments showed excellent systemic tolerability; rifaximin was completely tolerated also locally, while two cases of stomach ache were reported with the reference drug.
Comparison of two non-absorbable antibiotics for treatment of bacterial enteritis in children / Beseghi U.; De' Angelis G.L.. - In: RIVISTA EUROPEA PER LE SCIENZE MEDICHE E FARMACOLOGICHE. - ISSN 0392-291X. - 2 (3-4)(1996), pp. 131-136.
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