Antibodies (ICA and other organ-specific and non-organ-specific antibodies), HLA histocompatibility antigens and serum IgE levels were analysed in 27 diabetic children aged 2 to 14 years. The results obtained are as follows: 59% of examined subjects had ICA; the HLA-B8 incidence in our diabetic patients was significantly higher (p < 0.0005) than in normal population; serum IgE levels were higher than +1 SD in 67% of patients; this percentage reaches 76% in diabetics with ICA and 86% in diabetics with ICA and HLA-B8. Enhancement of IgE production could be the consequence of a reduction in the number and/or function of suppressor T lymphocytes.
Total IgE synthesis in diabetic children / Cavagni G; Vanelli M; Nori G; Piccione AM; Bernasconi S.. - In: ARCHIVES FRANCAISES DE PEDIATRIE. - ISSN 0003-9764. - 40(1983), pp. 319-321.
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