Two patients who developed thrombocytopenia while on Tiopronin and gold salts respectively were HLA typed. Their common haplotype was A25(10), B8, DR3. A survey of the literature showed that the association between DR3 and the sudden onset form of thrombocytopenia is striking. A genetic predisposition, besides other unknown factors, seems to play a crucial role.
Association between DR3 and thrombocytopenia due to gold or tiopronin. Case reports and review of the literature / G. Ferraccioli; F. Cavalieri; M. Mercadanti; F. Salaffi; U. Ambanelli; M. Savi.. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - Dec 3(4)(1985), pp. 341-343.
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