Old subjects exhibit a decline in circulating T cells and an impaired proliferative response to mitogens, plus a relative increase in cells with NK phenotype not associated with a concomitant increase in their cytolitic activity.In the present study a limiting dilution assay was used to evaluate the phenotype, the functional activity and the proliferative capacity of clones obtained from peripheral blood lymphocytes of old and young subjects. CD5+ CD8+ clones from old people showed a significant impairment in their proliferative capacity and a decreased lytic activity against K562 and P815-IgG cell lines.
Lymphocyte clones from old subjects: growing rate and functional activity / Mariani E; Roda P; Mariani AR; Vitale M; Degrassi A; Papa S; Manzoli FA; Facchini A.. - In: CYTOTECHNOLOGY. - ISSN 0920-9069. - 1(1)(1987), pp. 103-105.
|Tipologia ministeriale:||Articolo su rivista|
|Appare nelle tipologie:||1.1 Articolo su rivista|