Atrial fibrillation occurs and maintains itself in the context of a morphologically and functionally altered atrial substrate that can be induced by stressors such as underlying diseases (cardiac or noncardiac) or aging. The resultant structural remodeling is a slow process that progressively affects myocytes and the myocardial interstitium, and takes place from as early as the first days of atrial tachyarrhythmia. The left atrium, and particularly its posterior wall, is the location where remodeling is concentrated to the greatest extent. The mechanisms that underlie the remodeling process in atrial fibrillation have not yet been completely elucidated, although experimental and clinical investigations have indicated a number of signaling systems, inflammation, oxidative stress, atrial stretching and ischemia as factors involved in the cascade of events that leads to atrial fibrillation. The aim of this Review is to provide a comprehensive overview of the morphological changes that characterize the fibrillating atrial myocardium at histological and ultrastructural levels, and the established and hypothetical pathogenetic mechanisms involved in structural remodeling. This article also highlights the emerging therapies being developed to prevent progression of atrial fibrillation.

Structural remodeling in atrial fibrillation / Corradi, Domenico; Callegari, S; Maestri, Roberta; Benussi, S; Alfieri, O.. - In: NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE. - ISSN 1743-4297. - 5:(2008), pp. 782-796. [10.1038/ncpcardio1370]

Structural remodeling in atrial fibrillation.

CORRADI, Domenico;MAESTRI, Roberta;
2008-01-01

Abstract

Atrial fibrillation occurs and maintains itself in the context of a morphologically and functionally altered atrial substrate that can be induced by stressors such as underlying diseases (cardiac or noncardiac) or aging. The resultant structural remodeling is a slow process that progressively affects myocytes and the myocardial interstitium, and takes place from as early as the first days of atrial tachyarrhythmia. The left atrium, and particularly its posterior wall, is the location where remodeling is concentrated to the greatest extent. The mechanisms that underlie the remodeling process in atrial fibrillation have not yet been completely elucidated, although experimental and clinical investigations have indicated a number of signaling systems, inflammation, oxidative stress, atrial stretching and ischemia as factors involved in the cascade of events that leads to atrial fibrillation. The aim of this Review is to provide a comprehensive overview of the morphological changes that characterize the fibrillating atrial myocardium at histological and ultrastructural levels, and the established and hypothetical pathogenetic mechanisms involved in structural remodeling. This article also highlights the emerging therapies being developed to prevent progression of atrial fibrillation.
2008
Structural remodeling in atrial fibrillation / Corradi, Domenico; Callegari, S; Maestri, Roberta; Benussi, S; Alfieri, O.. - In: NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE. - ISSN 1743-4297. - 5:(2008), pp. 782-796. [10.1038/ncpcardio1370]
File in questo prodotto:
File Dimensione Formato  
Corradi Nat Clin Pract Cardiovasc Med 2008.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 544.48 kB
Formato Adobe PDF
544.48 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2403751
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 108
  • ???jsp.display-item.citation.isi??? 100
social impact