Abstract Acantholytic carcinoma is a subtype of squamous carcinoma, characterized by tubular and alveolar formations as a consequence of the acantholysis. We report a case of vulvar squamous acantholytic carcinoma (VSAC) in a 69-year-old woman, who was admitted to our institution for vulvar pruritus and the presence of a large, bilateral, exophytic, and ulcerated lesion, measuring 7 x 8 cm. The patient had never received vulvar or pelvic radiation therapy. Pathological examination with an immunohistochemical study showed features of VSAC and high p16(INK4a) protein expression. Molecular study by polymerase chain reaction amplification of DNA tumor revealed a weakly positive signal for human papillomavirus. In conclusion, our case, which is the first case of VSAC with polymerase chain reaction analysis and immunohistochemical expression of p16(INK4a) protein, suggested that this neoplasm could be related to human papillomavirus infection.

Vulvar acantholytic squamous carcinoma: a case report with immunohistochemical and molecular study / Giordano, Giovanna; D'Adda, Tiziana; Merisio, Carla; Gnetti, Letizia. - In: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY. - ISSN 0277-1691. - 24:3(2005), pp. 303-306. [10.1097/01.pgp.0000157919.43978.f3]

Vulvar acantholytic squamous carcinoma: a case report with immunohistochemical and molecular study.

GIORDANO, Giovanna
;
D'ADDA, Tiziana;MERISIO, Carla;Letizia, Gnetti
2005-01-01

Abstract

Abstract Acantholytic carcinoma is a subtype of squamous carcinoma, characterized by tubular and alveolar formations as a consequence of the acantholysis. We report a case of vulvar squamous acantholytic carcinoma (VSAC) in a 69-year-old woman, who was admitted to our institution for vulvar pruritus and the presence of a large, bilateral, exophytic, and ulcerated lesion, measuring 7 x 8 cm. The patient had never received vulvar or pelvic radiation therapy. Pathological examination with an immunohistochemical study showed features of VSAC and high p16(INK4a) protein expression. Molecular study by polymerase chain reaction amplification of DNA tumor revealed a weakly positive signal for human papillomavirus. In conclusion, our case, which is the first case of VSAC with polymerase chain reaction analysis and immunohistochemical expression of p16(INK4a) protein, suggested that this neoplasm could be related to human papillomavirus infection.
2005
Vulvar acantholytic squamous carcinoma: a case report with immunohistochemical and molecular study / Giordano, Giovanna; D'Adda, Tiziana; Merisio, Carla; Gnetti, Letizia. - In: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY. - ISSN 0277-1691. - 24:3(2005), pp. 303-306. [10.1097/01.pgp.0000157919.43978.f3]
File in questo prodotto:
File Dimensione Formato  
Merisio Vulvar acantholytic squamous carcinoma.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 384.66 kB
Formato Adobe PDF
384.66 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2402530
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 13
social impact