The neuroleptic malignant syndrome (NMS) is an uncommon, but potentially fatal adverse event of neuroleptic medications, mainly described in polytherapy psychiatric patients. Although initially described mostly with typical neuroleptics, many atypical ones have also been associated with this syndrome more recently. An NMS is neither dose dependent nor related to the duration of the therapy. The recognized risk factors are: dehydration, stress, concomitant use of lithium, anticholinergic agents or some antidepressants. A very important and dangerous NMS complication is acute renal failure. We report an unusual case of NMS, in the absence of concomitant schizoaffective disorders. He descrive a case report of neuroleptic malignant syndrome
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