BACKGROUND: Epidermal growth factor receptor (EGFR) gene copy number has been proposed as predictor of response to epidermal growth factor receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer (NSCLC).METHODS: Cytologic and matched histologic samples from 33 primary non-small cell lung cancers were analyzed by fluorescence in situ hybridization (FISH) for epidermal growth factor receptor gene.RESULTS: FISH was positive in 52% and negative in 35% of the 31 matched evaluable samples. Four of 31 (13%) cases were discordant (K = 0.736; p < 0.001).CONCLUSION: Our data support the feasibility and reliability of epidermal growth factor receptor gene assessment by FISH on cytology.
Is cytology reliable for epidermal growth factor receptor gene evaluation in non-small cell lung cancer? / Bozzetti, C.; Tiseo, M.; Lagrasta, Costanza Anna Maria; Nizzoli, R.; Guazzi, A.; Graiani, G.; Rindi, G.; Ardizzoni, A.. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - 5:(2010), pp. 551-553. [10.1097/JTO.0b013e3181ce3b28]
Is cytology reliable for epidermal growth factor receptor gene evaluation in non-small cell lung cancer?
M. Tiseo;LAGRASTA, Costanza Anna Maria;
2010-01-01
Abstract
BACKGROUND: Epidermal growth factor receptor (EGFR) gene copy number has been proposed as predictor of response to epidermal growth factor receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer (NSCLC).METHODS: Cytologic and matched histologic samples from 33 primary non-small cell lung cancers were analyzed by fluorescence in situ hybridization (FISH) for epidermal growth factor receptor gene.RESULTS: FISH was positive in 52% and negative in 35% of the 31 matched evaluable samples. Four of 31 (13%) cases were discordant (K = 0.736; p < 0.001).CONCLUSION: Our data support the feasibility and reliability of epidermal growth factor receptor gene assessment by FISH on cytology.| File | Dimensione | Formato | |
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