The effects of dietary nucleotide supplementation from 9 days of age until the end of post-weaning on piglets hormonal and immune responses and on growth performance were investigated. During lactation (days 9 to 21) and post-weaning (days 22 to 55) 10 [HBI Fomeva11*(Large White*Landrace)] litters (n.108 piglets) had ad libitum access to two standard diets, both supplemented with 0% (T0 group) or 0.1% (T1 group) of yeast extract nucleotides. BW of piglets at days 21 ( P<0.10), 35 and 55 ( P<0.05) was greater in T1 compared with T0. Feed intake was not different between groups (P>0.05). Cortisol content was lower in T1 than in T0 at days 28 and 35 (P<0.05), whereas growth hormone was lower at day 35 ( P<0.05). Levels of IGF-1 were similar across groups ( P>0.05). Nucleotide-supplemented diets increased lymphocyte subpopulation CD4-CD8+high at days 21 and 35 (P<0.05), whereas CD4+CD8- cells were higher in T1 than in T0 at day 21 (P<0.05). Peripheral blood mononuclear cells cytokine expression was influenced by dietary nucleotide supplementation. At weaning, interleukin (IL)-6 and IL-1-beta expression was lower ( P<0.05) in T1 compared with T0, whereas the expression of interferon (IFN)-gamma and IL-10 was higher (P<0.05). At day 28, piglets in T1 showed higher values of tumor necrosis factor (TNF)-alfa expression than T0 and lower values of IL-10 expression (P<0.05). Dietary nucleotide supplementation had a suppressive effect on IL-6 and IL-10 expression (P<0.05) at day 35. On the contrary, the expression of IFN-gamma, TNF-alfa and IL-1-beta was enhanced (P<0.05). In conclusion, these results suggest that starting a dietary nucleotide supplementation before weaning can improve the adaptive capabilities of weaned piglets to the stressors, enhancing the growth performance.

Effects of dietary nucleotide supplementation on growth performance and hormonal and immune responses of piglets / Superchi, Paola; Saleri, Roberta; Borghetti, Paolo; DE ANGELIS, Elena; Ferrari, Luca; Cavalli, Valeria; Amicucci, Paolo; Ossiprandi, Maria Cristina; Sabbioni, Alberto. - In: ANIMAL. - ISSN 1751-7311. - 6:(2012), pp. 902-908. [10.1017/S1751731111002473]

Effects of dietary nucleotide supplementation on growth performance and hormonal and immune responses of piglets

SUPERCHI, Paola;SALERI, Roberta;BORGHETTI, Paolo;DE ANGELIS, Elena;FERRARI, Luca;CAVALLI, Valeria;AMICUCCI, Paolo;OSSIPRANDI, Maria Cristina;SABBIONI, Alberto
2012

Abstract

The effects of dietary nucleotide supplementation from 9 days of age until the end of post-weaning on piglets hormonal and immune responses and on growth performance were investigated. During lactation (days 9 to 21) and post-weaning (days 22 to 55) 10 [HBI Fomeva11*(Large White*Landrace)] litters (n.108 piglets) had ad libitum access to two standard diets, both supplemented with 0% (T0 group) or 0.1% (T1 group) of yeast extract nucleotides. BW of piglets at days 21 ( P<0.10), 35 and 55 ( P<0.05) was greater in T1 compared with T0. Feed intake was not different between groups (P>0.05). Cortisol content was lower in T1 than in T0 at days 28 and 35 (P<0.05), whereas growth hormone was lower at day 35 ( P<0.05). Levels of IGF-1 were similar across groups ( P>0.05). Nucleotide-supplemented diets increased lymphocyte subpopulation CD4-CD8+high at days 21 and 35 (P<0.05), whereas CD4+CD8- cells were higher in T1 than in T0 at day 21 (P<0.05). Peripheral blood mononuclear cells cytokine expression was influenced by dietary nucleotide supplementation. At weaning, interleukin (IL)-6 and IL-1-beta expression was lower ( P<0.05) in T1 compared with T0, whereas the expression of interferon (IFN)-gamma and IL-10 was higher (P<0.05). At day 28, piglets in T1 showed higher values of tumor necrosis factor (TNF)-alfa expression than T0 and lower values of IL-10 expression (P<0.05). Dietary nucleotide supplementation had a suppressive effect on IL-6 and IL-10 expression (P<0.05) at day 35. On the contrary, the expression of IFN-gamma, TNF-alfa and IL-1-beta was enhanced (P<0.05). In conclusion, these results suggest that starting a dietary nucleotide supplementation before weaning can improve the adaptive capabilities of weaned piglets to the stressors, enhancing the growth performance.
Effects of dietary nucleotide supplementation on growth performance and hormonal and immune responses of piglets / Superchi, Paola; Saleri, Roberta; Borghetti, Paolo; DE ANGELIS, Elena; Ferrari, Luca; Cavalli, Valeria; Amicucci, Paolo; Ossiprandi, Maria Cristina; Sabbioni, Alberto. - In: ANIMAL. - ISSN 1751-7311. - 6:(2012), pp. 902-908. [10.1017/S1751731111002473]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2374300
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