In this study the anticonvulsant activity evaluation of a series of new 2,4(1H)-diarylimidazoles, characterized by the presence of different substituents on the aryl rings, was described. The anticonvulsant activity profile of those compounds was determined by maximal electroshock seizure (MES), subcutaneous metrazol seizure (scMet) tests and 6-Hz seizure model, whereas their neurotoxicity was examined using rotarod test. The trifluorimethoxy derivative, obtained starting from phenylglyoxal, p-OCF3-benzaldehyde, and ammonium acetate in methanol (r.t.), exhibited a great ability to prevent the seizures induced in the 6-Hz test, becoming a new promising molecule to develop for the treatment of therapy-resistant partial seizures.
In vivo Screening of Diarylimidazoles as Anticonvulsant Agents / Rivara, Mirko; Zuliani, Valentina. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - 21:(2012), pp. 3428-3434. [10.1007/s00044-011-9869-0]
In vivo Screening of Diarylimidazoles as Anticonvulsant Agents
RIVARA, Mirko;ZULIANI, Valentina
2012-01-01
Abstract
In this study the anticonvulsant activity evaluation of a series of new 2,4(1H)-diarylimidazoles, characterized by the presence of different substituents on the aryl rings, was described. The anticonvulsant activity profile of those compounds was determined by maximal electroshock seizure (MES), subcutaneous metrazol seizure (scMet) tests and 6-Hz seizure model, whereas their neurotoxicity was examined using rotarod test. The trifluorimethoxy derivative, obtained starting from phenylglyoxal, p-OCF3-benzaldehyde, and ammonium acetate in methanol (r.t.), exhibited a great ability to prevent the seizures induced in the 6-Hz test, becoming a new promising molecule to develop for the treatment of therapy-resistant partial seizures.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
