Data on sex differences in emphysema are limited to chronic obstructive pulmonary disease. We aimed to verify whether such differences also exist in smokers without airflow obstruction, weighting their influence on the relationship between emphysema and clinical features. We evaluated both clinical and multidetector computed tomography (MDCT) data of 1,011 heavy smokers recruited by a lung cancer screening project. MDCT scans were analysed with software allowing lobar quantification of emphysema features. For these measures, multiple regression models were applied to assess the effect of patients sex, after allowance for age, body mass index (BMI), smoking history, forced expiratory volume in 1 s (FEV(1)) and forced vital capacity. The final study cohort consisted of 957 smokers without airflow obstruction. Compared with males, females exhibited an emphysema phenotype less extensive in each pulmonary lobe, characterised by smaller emphysematous areas and less concentrated in the core of the lung. However, in females, the increase of emphysema with age was more pronounced and displayed a more significant relationship with FEV(1)\% decline; conversely, in males there was a stronger association with the decrease in BMI. Males and females respond differently to the type and location of lung damage due to tobacco exposure. In smokers, sex influences the relationship between emphysema and clinical features.

Sex differences in emphysema phenotype in smokers without airflow obstruction / Sverzellati, Nicola; Calabrò, Elisa; Randi, Giorgia; La Vecchia, Carlo; Marchianò, Alfonso V; Kuhnigk, Jan Martin; Zompatori, Maurizio; Spagnolo, Paolo; Pastorino, Ugo. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - 33:6(2009), pp. 1320-1328. [10.1183/09031936.00109808]

Sex differences in emphysema phenotype in smokers without airflow obstruction.

SVERZELLATI, Nicola;
2009

Abstract

Data on sex differences in emphysema are limited to chronic obstructive pulmonary disease. We aimed to verify whether such differences also exist in smokers without airflow obstruction, weighting their influence on the relationship between emphysema and clinical features. We evaluated both clinical and multidetector computed tomography (MDCT) data of 1,011 heavy smokers recruited by a lung cancer screening project. MDCT scans were analysed with software allowing lobar quantification of emphysema features. For these measures, multiple regression models were applied to assess the effect of patients sex, after allowance for age, body mass index (BMI), smoking history, forced expiratory volume in 1 s (FEV(1)) and forced vital capacity. The final study cohort consisted of 957 smokers without airflow obstruction. Compared with males, females exhibited an emphysema phenotype less extensive in each pulmonary lobe, characterised by smaller emphysematous areas and less concentrated in the core of the lung. However, in females, the increase of emphysema with age was more pronounced and displayed a more significant relationship with FEV(1)\% decline; conversely, in males there was a stronger association with the decrease in BMI. Males and females respond differently to the type and location of lung damage due to tobacco exposure. In smokers, sex influences the relationship between emphysema and clinical features.
Sex differences in emphysema phenotype in smokers without airflow obstruction / Sverzellati, Nicola; Calabrò, Elisa; Randi, Giorgia; La Vecchia, Carlo; Marchianò, Alfonso V; Kuhnigk, Jan Martin; Zompatori, Maurizio; Spagnolo, Paolo; Pastorino, Ugo. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - 33:6(2009), pp. 1320-1328. [10.1183/09031936.00109808]
File in questo prodotto:
File Dimensione Formato  
Sex differences in emphysema phenotype ERJ 09.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 554.8 kB
Formato Adobe PDF
554.8 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2338428
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 34
  • ???jsp.display-item.citation.isi??? 34
social impact