The relationship between smoking, lung cancer and airflow obstruction is recognised but it is unclear whether the presence of minimal lung function damage constitutes an independent risk factor for the development of lung cancer. In order to identify those individuals at higher risk of lung cancer on the basis of functional impairment, we evaluated baseline pulmonary function tests of 3,806 heavy smokers undergoing annual chest computed tomography screening, and compared the forced expiratory volume in 1 s (FEV(1)) \% predicted of 57 lung cancer cases and that of 3,749 subjects without cancer. We obtained odds ratios (ORs) of lung cancer and the corresponding 95\% confidence intervals (CIs) using unconditional logistic regression, adjusting for age, sex, study and smoking variables. Compared with subjects with FEV(1) >or=90\% pred, the OR of lung cancer was 2.45 (95\% CI 1.39-4.33) for subjects with FEV(1) <90\% pred and 2.90 (95\% CI 1.34-6.27) for subjects with FEV(1) <70\% pred. These data show that even a relatively small reduction in FEV(1) \% pred is a significant predictor of increased lung cancer risk. Test screening for lung cancer using airflow obstruction with FEV(1) <90\% is a strategy worth future consideration.

Lung function predicts lung cancer risk in smokers: a tool for targeting screening programmes / Calabrò, Elisa; Randi, Giorgia; La Vecchia, Carlo LA; Sverzellati, Nicola; Marchianò, Alfonso V; Villani, Massimiliano; Zompatori, Maurizio; Cassandro, Roberto; Harari, Sergio; Pastorino, Ugo. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - 35:(2010), pp. 146-151. [10.1183/09031936.00049909]

Lung function predicts lung cancer risk in smokers: a tool for targeting screening programmes.

SVERZELLATI, Nicola;
2010-01-01

Abstract

The relationship between smoking, lung cancer and airflow obstruction is recognised but it is unclear whether the presence of minimal lung function damage constitutes an independent risk factor for the development of lung cancer. In order to identify those individuals at higher risk of lung cancer on the basis of functional impairment, we evaluated baseline pulmonary function tests of 3,806 heavy smokers undergoing annual chest computed tomography screening, and compared the forced expiratory volume in 1 s (FEV(1)) \% predicted of 57 lung cancer cases and that of 3,749 subjects without cancer. We obtained odds ratios (ORs) of lung cancer and the corresponding 95\% confidence intervals (CIs) using unconditional logistic regression, adjusting for age, sex, study and smoking variables. Compared with subjects with FEV(1) >or=90\% pred, the OR of lung cancer was 2.45 (95\% CI 1.39-4.33) for subjects with FEV(1) <90\% pred and 2.90 (95\% CI 1.34-6.27) for subjects with FEV(1) <70\% pred. These data show that even a relatively small reduction in FEV(1) \% pred is a significant predictor of increased lung cancer risk. Test screening for lung cancer using airflow obstruction with FEV(1) <90\% is a strategy worth future consideration.
2010
Lung function predicts lung cancer risk in smokers: a tool for targeting screening programmes / Calabrò, Elisa; Randi, Giorgia; La Vecchia, Carlo LA; Sverzellati, Nicola; Marchianò, Alfonso V; Villani, Massimiliano; Zompatori, Maurizio; Cassandro, Roberto; Harari, Sergio; Pastorino, Ugo. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - 35:(2010), pp. 146-151. [10.1183/09031936.00049909]
File in questo prodotto:
File Dimensione Formato  
Lung function predicts lung cancer risk in smokers Eur Resp J 09.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 263.57 kB
Formato Adobe PDF
263.57 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2338420
Citazioni
  • ???jsp.display-item.citation.pmc??? 26
  • Scopus 76
  • ???jsp.display-item.citation.isi??? 63
social impact