Oral postinflammatory pigmentation: An analysis of 7 cases.

Oral postinflammatory pigmentation (OPP) is a discoloration of the oral mucosa caused by an excess of melanin production and deposition within the basal layer of the epithelium and connective tissue of areas affected by chronic inflammation. Therefore, it is mandatory to demonstrate the association with a previous or concomitant inflammatory process in the same area of oral mucosa. Clinically OPP appears as a localized or diffuse, black to brown pigmentation. OPP may persist for many years even though the disappearing of the pigmentation after the resolution of the inflammatory state has been reported. We reviewed retrospectively the medical records and, when performed, biopsy examinations of 7 cases of OPP. Four cases were associated with oral lichen planus, two cases with lichenoid lesions and one case with proliferative verrucous leukoplakia. Despite a possible high prevalence of OPP, only a few reports concerning diagnosis, etiopathogenesis and clinical manifestation have been published so far.