A new one-step procedure for the synthesis of monoalkylated calix[4]arenes is presented. Reaction of calix[4]arene 1a or 1b with 1.2 equivalent of a weak base (K2CO3 in MeCN or CsF in DMF) and excess of alkylating agent affords the monoalkylated calix[4]arenes in moderate to good yields.
Synthesis of Monoalkylated Calix[4]arenes via Direct Alkylation / L. C., Groenen; B. H. M., Ruel; Casnati, Alessandro; W., Verboom; Pochini, Andrea; Ungaro, Rocco; D. N., Reinhoudt. - In: TETRAHEDRON. - ISSN 0040-4020. - 47:(1991), pp. 8379-8384. [10.1016/S0040-4020(01)96179-4]
Synthesis of Monoalkylated Calix[4]arenes via Direct Alkylation
CASNATI, Alessandro;POCHINI, Andrea;UNGARO, Rocco;
1991-01-01
Abstract
A new one-step procedure for the synthesis of monoalkylated calix[4]arenes is presented. Reaction of calix[4]arene 1a or 1b with 1.2 equivalent of a weak base (K2CO3 in MeCN or CsF in DMF) and excess of alkylating agent affords the monoalkylated calix[4]arenes in moderate to good yields.File in questo prodotto:
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