Some first row transition metal(II) complexes of imidazole-2-carbaldehyde semicarbazone (H2L) have been synthesised and characterised. Single crystal X-ray diffraction studies have revealed the molecular structure of the neutral complex NiCl2(H2L)(H2O). This latter complex shows a pseudo-octahedral geometry, with both chloride ions displaying a cis disposition. The asymmetry of this complex allows the formation of two enantiomers in the racemic crystal structure. The non-deprotonated semicarbazone ligand behaves as an N,N,O-donor, through the imidazole and imine N atoms and the Oketo atom. The coordinative behaviour of H2L in CuCl2(H2L)(H2O), ZnCl2(H2L)20.5EtOH and CoCl2(H2L)20.5H2O is reported as only N,O-donor. The antimicrobial activity of the semicarbazone ligand and its metal complexes has been tested against some representative bacteria and fungi. A moderate inhibitory activity of the cobalt complex was detected towards the assayed phytopathogenic fungi Alternaria tenuis and Sclerotinia minor (MIC 50 microg/mL).

Evaluation of the antimicrobial activity of some chloro complexes of imidazole-2-carbaldehyde semicarbazone: X-ray crystal structure of cis-NiCl2(H2L)(H2O) / Rodríguez Argüelles, M. C.; Mosquera Vázquez, S.; Sanmartín Matalobos, J.; García Deibe, A. M.; Pelizzi, Corrado; Zani, Franca. - In: POLYHEDRON. - ISSN 0277-5387. - 29:(2010), pp. 864-870. [10.1016/j.poly.2009.10.011]

Evaluation of the antimicrobial activity of some chloro complexes of imidazole-2-carbaldehyde semicarbazone: X-ray crystal structure of cis-NiCl2(H2L)(H2O)

PELIZZI, CORRADO;ZANI, Franca
2010-01-01

Abstract

Some first row transition metal(II) complexes of imidazole-2-carbaldehyde semicarbazone (H2L) have been synthesised and characterised. Single crystal X-ray diffraction studies have revealed the molecular structure of the neutral complex NiCl2(H2L)(H2O). This latter complex shows a pseudo-octahedral geometry, with both chloride ions displaying a cis disposition. The asymmetry of this complex allows the formation of two enantiomers in the racemic crystal structure. The non-deprotonated semicarbazone ligand behaves as an N,N,O-donor, through the imidazole and imine N atoms and the Oketo atom. The coordinative behaviour of H2L in CuCl2(H2L)(H2O), ZnCl2(H2L)20.5EtOH and CoCl2(H2L)20.5H2O is reported as only N,O-donor. The antimicrobial activity of the semicarbazone ligand and its metal complexes has been tested against some representative bacteria and fungi. A moderate inhibitory activity of the cobalt complex was detected towards the assayed phytopathogenic fungi Alternaria tenuis and Sclerotinia minor (MIC 50 microg/mL).
2010
Evaluation of the antimicrobial activity of some chloro complexes of imidazole-2-carbaldehyde semicarbazone: X-ray crystal structure of cis-NiCl2(H2L)(H2O) / Rodríguez Argüelles, M. C.; Mosquera Vázquez, S.; Sanmartín Matalobos, J.; García Deibe, A. M.; Pelizzi, Corrado; Zani, Franca. - In: POLYHEDRON. - ISSN 0277-5387. - 29:(2010), pp. 864-870. [10.1016/j.poly.2009.10.011]
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