Chemotherapy-associated peripheral sensory neuropathy assessed using in vivo corneal confocal microscopy

Peripheral neuropathies are a frequent complication of antineoplastic therapy. Capecitabine is known to induce peripheral sensory neuropathy. However, the diagnosis requires invasive examinations such as electrophysiology tests or peripheral skin biopsy. In vivo confocal microscopy represents a promising, noninvasive new tool in the study of chemotherapy-induced peripheral neuropathy, which often occurs in complex patients who are not always willing to have further testing. In vivo confocal microscopy should be considered a useful tool in the diagnosis and follow-up of chemotherapy-induced peripheral neuropathies, given its low invasiveness, repeatability, and low cost.