Chemogenomics aims towards the systematic identification of small molecules that interact with the products of the genome and modulate their biological function. The establishment and expansion of a comprehensive ligand-target Structure-Activity Relationship matrix is following the elucidation of the human genome a key scientific challenge for the 21st century. Small chemical compounds are the first dimension of the ligand-target SAR matrix. Accordingly, the systematic expansion of the physically available and bioactive chemical space is a key objective of chemogenomics. The vital question is, how to enlarge the physically existing chemical space into the bioactive and drug-like spaces? Effective systematic expansion of the chemical space to reach a maximum of biological binding sites appears possible when conserved molecular recognition principles are the founding hypothesis for the design of the compounds. Such principles, including approaches focusing on target families, privileged scaffolds, protein secondary structure mimetics, co-factor mimetics, and DOS and BIOS libraries are summarized in this mini-review article.

Chemogenomic Strategies to Expand the Bioactive Chemical Space / E., Jacoby; Mozzarelli, Andrea. - In: CURRENT MEDICINAL CHEMISTRY. - ISSN 0929-8673. - 16:(2009), pp. 4374-4381. [10.2174/092986709789712862]

Chemogenomic Strategies to Expand the Bioactive Chemical Space

MOZZARELLI, Andrea
2009-01-01

Abstract

Chemogenomics aims towards the systematic identification of small molecules that interact with the products of the genome and modulate their biological function. The establishment and expansion of a comprehensive ligand-target Structure-Activity Relationship matrix is following the elucidation of the human genome a key scientific challenge for the 21st century. Small chemical compounds are the first dimension of the ligand-target SAR matrix. Accordingly, the systematic expansion of the physically available and bioactive chemical space is a key objective of chemogenomics. The vital question is, how to enlarge the physically existing chemical space into the bioactive and drug-like spaces? Effective systematic expansion of the chemical space to reach a maximum of biological binding sites appears possible when conserved molecular recognition principles are the founding hypothesis for the design of the compounds. Such principles, including approaches focusing on target families, privileged scaffolds, protein secondary structure mimetics, co-factor mimetics, and DOS and BIOS libraries are summarized in this mini-review article.
2009
Chemogenomic Strategies to Expand the Bioactive Chemical Space / E., Jacoby; Mozzarelli, Andrea. - In: CURRENT MEDICINAL CHEMISTRY. - ISSN 0929-8673. - 16:(2009), pp. 4374-4381. [10.2174/092986709789712862]
File in questo prodotto:
File Dimensione Formato  
abstract Jacoby-Mozzarelli CMC.pdf

non disponibili

Tipologia: Abstract
Licenza: Creative commons
Dimensione 18.96 kB
Formato Adobe PDF
18.96 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Jacoby_CMC.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 197.49 kB
Formato Adobe PDF
197.49 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2303728
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 25
social impact