The effects of selective a2-agonists (xylazine, detomidine and medetomidine) and antagonists (yohim- bine and atipamezole) on in vitro small intestine motility in the horse were evaluated. Samples of equine jejunum were placed in isolated organ baths and drug-induced modifications of motility were measured by means of an isotonic transducer. All tested a2-agonists dose-dependently reduced both spontaneous and electrically-evoked phasic contractions. Conversely, a2-antagonists were ineffective when tested alone, and showed a heterogeneous and dose-independent ability to inhibit agonist activity. In particular, the antagonism exerted by higher concentrations of both yohimbine and atipamezole against a2-agonists was weaker than when lower concentrations were used. The data are indicative of the presence of both pre- and post-synaptic a2-adrenoceptors with inhibitory activity on equine jejunum motility, and sup- port a possible therapeutic utility of these drugs in horse intestinal disorders associated with hypermotility.

Effects of alpha(2)-adrenergic drugs on small intestinal motility in the horse: An in vitro study / Zullian, C.; Menozzi, Alessandro; Pozzoli, Cristina; Poli, Enzo; Bertini, Simone. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 187:(2011), pp. 342-346. [10.1016/j.tvjl.2009.12.015]

Effects of alpha(2)-adrenergic drugs on small intestinal motility in the horse: An in vitro study

MENOZZI, Alessandro;POZZOLI, Cristina;POLI, Enzo;BERTINI, Simone
2011-01-01

Abstract

The effects of selective a2-agonists (xylazine, detomidine and medetomidine) and antagonists (yohim- bine and atipamezole) on in vitro small intestine motility in the horse were evaluated. Samples of equine jejunum were placed in isolated organ baths and drug-induced modifications of motility were measured by means of an isotonic transducer. All tested a2-agonists dose-dependently reduced both spontaneous and electrically-evoked phasic contractions. Conversely, a2-antagonists were ineffective when tested alone, and showed a heterogeneous and dose-independent ability to inhibit agonist activity. In particular, the antagonism exerted by higher concentrations of both yohimbine and atipamezole against a2-agonists was weaker than when lower concentrations were used. The data are indicative of the presence of both pre- and post-synaptic a2-adrenoceptors with inhibitory activity on equine jejunum motility, and sup- port a possible therapeutic utility of these drugs in horse intestinal disorders associated with hypermotility.
2011
Effects of alpha(2)-adrenergic drugs on small intestinal motility in the horse: An in vitro study / Zullian, C.; Menozzi, Alessandro; Pozzoli, Cristina; Poli, Enzo; Bertini, Simone. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 187:(2011), pp. 342-346. [10.1016/j.tvjl.2009.12.015]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2300990
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