Oxytocin (OT) effect on ghrelin-stimulated neuropeptide Y (NPY) secretion was evaluated in 12 normal men. Tests: ghrelin (1 microg/kg B.W. as an intravenous bolus); OT (2 mIU/min infusion); ghrelin plus OT; normal saline. Plasma NPY did not change during saline or OT infusions, whereas it showed a significant 29% increase vs baseline at 15 min after ghrelin injection. When OT was present, ghrelin-induced NPY increment was completely abolished. Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels.
Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans / Coiro, Vittorio; Saccani, Gloria; Rubino, P; Manfredi, G; Vacca, P; Volta, E; Chiodera, Paolo. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - 115:(2008), pp. 1265-1267. [10.1007/s00702-008-0057-0]
Oxytocin inhibits the stimulatory effect of ghrelin on circulating neuropeptide Y levels in humans
COIRO, Vittorio;SACCANI, Gloria;CHIODERA, Paolo
2008-01-01
Abstract
Oxytocin (OT) effect on ghrelin-stimulated neuropeptide Y (NPY) secretion was evaluated in 12 normal men. Tests: ghrelin (1 microg/kg B.W. as an intravenous bolus); OT (2 mIU/min infusion); ghrelin plus OT; normal saline. Plasma NPY did not change during saline or OT infusions, whereas it showed a significant 29% increase vs baseline at 15 min after ghrelin injection. When OT was present, ghrelin-induced NPY increment was completely abolished. Results show that oxytocin modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels.| File | Dimensione | Formato | |
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