The biological function of Clusterin has been puzzling researchers for a long time since its first discovery and characterization in the early 80’s. CLU plays important roles nearly in all most important biological phenomena including cell proliferation and apoptosis, as well as in many diseases including cancer. Now we know that the CLU gene encodes at least three protein forms with different sub-cellular localization and diverse biological functions. The molecular mechanism of production of these protein isoforms remains unclear. Recent data show that many of the previous hypotheses based on preliminary observations are no longer true. For instance, while alternative splicing of CLU mRNA has never been confirmed, the complex transcriptional regulation of CLU gene is now recognized to produce two distinct transcripts resulting from two independent transcriptional start sites. CLU expression was found deregulated in many type of tumours, including prostate cancer. Considering that prostate cancer is one of the major threats in veterans’ life, as well as one of the main causes of cancer related death in western countries, we will also specifically address whether targeting CLU might pave the way for a novel therapeutic intervention against prostate cancer

Targeting clusterin in prostate cancer / Rizzi, Federica Maria Angela; Bettuzzi, Saverio. - In: JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. - ISSN 0867-5910. - 59 Suppl 9:(2008), pp. 265-274.

Targeting clusterin in prostate cancer

RIZZI, Federica Maria Angela;BETTUZZI, Saverio
2008-01-01

Abstract

The biological function of Clusterin has been puzzling researchers for a long time since its first discovery and characterization in the early 80’s. CLU plays important roles nearly in all most important biological phenomena including cell proliferation and apoptosis, as well as in many diseases including cancer. Now we know that the CLU gene encodes at least three protein forms with different sub-cellular localization and diverse biological functions. The molecular mechanism of production of these protein isoforms remains unclear. Recent data show that many of the previous hypotheses based on preliminary observations are no longer true. For instance, while alternative splicing of CLU mRNA has never been confirmed, the complex transcriptional regulation of CLU gene is now recognized to produce two distinct transcripts resulting from two independent transcriptional start sites. CLU expression was found deregulated in many type of tumours, including prostate cancer. Considering that prostate cancer is one of the major threats in veterans’ life, as well as one of the main causes of cancer related death in western countries, we will also specifically address whether targeting CLU might pave the way for a novel therapeutic intervention against prostate cancer
Targeting clusterin in prostate cancer / Rizzi, Federica Maria Angela; Bettuzzi, Saverio. - In: JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. - ISSN 0867-5910. - 59 Suppl 9:(2008), pp. 265-274.
File in questo prodotto:
File Dimensione Formato  
Rizzi Bettuzzi JPP 2008.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: Creative commons
Dimensione 137.19 kB
Formato Adobe PDF
137.19 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2296118
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 21
social impact