BACKGROUND: This work is aimed at comparing mucinous colorectal adenocarcinomas (MUC) and non-mucinous colorectal adenocarcinomas (non-MUC), and at verifying the existence of two different subgroups of MUC, in terms of clinicopathological features, chromosomal alterations, and outcome, in a geographical area where mucinous colorectal cancer resulted as being very frequent. METHODS: One hundred and fifty-six unselected patients who underwent curative colorectal resection for sporadic colorectal cancer over a 4-year period were evaluated for histological classification as to MUC and non-MUC subtype, for microsatellite instability (MSI) using six microsatellite markers, and for the presence of p27, Fhit, and cyclooxygenase-2 (Cox-2). Molecular data, immunohistochemical results, recurrence frequency, and patient survival were analyzed statistically in relation to histological subtypes. RESULTS: MUC accounted for 38.5% of all colorectal carcinomas. Compared to non-MUCs, MUCs were more frequently located in the proximal colon (p < 0.001), and more frequently showed MSI phenotype (p < 0.001), altered protein expression of hMlh1 (p = 0.030), Fhit (p <0.001), and p27 (p < 0.001). Compared to MUC with microsatellite-stable (MSS) phenotype, MUC with MSI more frequently resulted as being located in the proximal colon (p = 0.013), and more frequently showed altered expression of hMlh1 (p < 0.001), hMsh2 (p = 0.008), Fhit (p < 0.001), and p27 (p = 0.015). Significantly better survival of patients with proximal MUC (p = 0,012), with MSI MUC (p = 0.017), and with MUC with altered p27 expression (p = 0.02). CONCLUSION: The results of the present study confirm that MUC represents distinct clinicopathological and genetic features as compared to non-mucinous tumors and support the hypothesis that MUC includes two subtypes with different genetic pathways and behavior.

Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features / Sarli, Leopoldo; Bottarelli, Lorena; Azzoni, Cinzia; Dicola, G; Barilli, Al; Costi, Renato; Mazzeo, A; Salvemini, C; Porrini, C; Cecchini, Stefano; Taglia, M; Roncoroni, Luigi; Bordi, C.. - In: ANNALS OF SURGICAL ONCOLOGY. - ISSN 1068-9265. - 15 (5):(2008), pp. 1429-1439. [10.1245/s10434-007-9757-1]

Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features

SARLI, Leopoldo;BOTTARELLI, Lorena;AZZONI, Cinzia;COSTI, Renato;CECCHINI, Stefano;RONCORONI, Luigi;
2008-01-01

Abstract

BACKGROUND: This work is aimed at comparing mucinous colorectal adenocarcinomas (MUC) and non-mucinous colorectal adenocarcinomas (non-MUC), and at verifying the existence of two different subgroups of MUC, in terms of clinicopathological features, chromosomal alterations, and outcome, in a geographical area where mucinous colorectal cancer resulted as being very frequent. METHODS: One hundred and fifty-six unselected patients who underwent curative colorectal resection for sporadic colorectal cancer over a 4-year period were evaluated for histological classification as to MUC and non-MUC subtype, for microsatellite instability (MSI) using six microsatellite markers, and for the presence of p27, Fhit, and cyclooxygenase-2 (Cox-2). Molecular data, immunohistochemical results, recurrence frequency, and patient survival were analyzed statistically in relation to histological subtypes. RESULTS: MUC accounted for 38.5% of all colorectal carcinomas. Compared to non-MUCs, MUCs were more frequently located in the proximal colon (p < 0.001), and more frequently showed MSI phenotype (p < 0.001), altered protein expression of hMlh1 (p = 0.030), Fhit (p <0.001), and p27 (p < 0.001). Compared to MUC with microsatellite-stable (MSS) phenotype, MUC with MSI more frequently resulted as being located in the proximal colon (p = 0.013), and more frequently showed altered expression of hMlh1 (p < 0.001), hMsh2 (p = 0.008), Fhit (p < 0.001), and p27 (p = 0.015). Significantly better survival of patients with proximal MUC (p = 0,012), with MSI MUC (p = 0.017), and with MUC with altered p27 expression (p = 0.02). CONCLUSION: The results of the present study confirm that MUC represents distinct clinicopathological and genetic features as compared to non-mucinous tumors and support the hypothesis that MUC includes two subtypes with different genetic pathways and behavior.
2008
Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features / Sarli, Leopoldo; Bottarelli, Lorena; Azzoni, Cinzia; Dicola, G; Barilli, Al; Costi, Renato; Mazzeo, A; Salvemini, C; Porrini, C; Cecchini, Stefano; Taglia, M; Roncoroni, Luigi; Bordi, C.. - In: ANNALS OF SURGICAL ONCOLOGY. - ISSN 1068-9265. - 15 (5):(2008), pp. 1429-1439. [10.1245/s10434-007-9757-1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2295704
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