A mild treatment of the resveratrol analogue 3,5,4'-trimethoxystilbene 2 with m-CPBA afforded two hydroxylated methoxystilbenes 5 and 6 by direct aromatic hydroxylation. A similar protocol was applied to other stilbenes bearing a 3,5-dimethoxy moiety, namely tetramethoxystilbenes 7 and 10 to obtain respectively the hydroxylated analogues 8, 9 and 11, 12. The Substrate 2 and the new compounds 5, 8 and 11 were evaluated as anti-angiogenic agents and proved significantly active in the range 1 - 100 mu M.
Antiangiogenic Resveratrol Analogues by Mild m-CPBA Aromatic Hydroxylation of 3,5-Dimethoxystilbenes / Spatafora, C; Basini, Giuseppina; Baioni, Laura; Grasselli, Francesca; Sofia, A; Tringali, C.. - In: NATURAL PRODUCT COMMUNICATIONS. - ISSN 1934-578X. - 4:(2009), pp. 239-246.
Antiangiogenic Resveratrol Analogues by Mild m-CPBA Aromatic Hydroxylation of 3,5-Dimethoxystilbenes
BASINI, Giuseppina;BAIONI, Laura;GRASSELLI, Francesca;
2009-01-01
Abstract
A mild treatment of the resveratrol analogue 3,5,4'-trimethoxystilbene 2 with m-CPBA afforded two hydroxylated methoxystilbenes 5 and 6 by direct aromatic hydroxylation. A similar protocol was applied to other stilbenes bearing a 3,5-dimethoxy moiety, namely tetramethoxystilbenes 7 and 10 to obtain respectively the hydroxylated analogues 8, 9 and 11, 12. The Substrate 2 and the new compounds 5, 8 and 11 were evaluated as anti-angiogenic agents and proved significantly active in the range 1 - 100 mu M.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
