Cobalt(II), nickel(II), copper(II) and zinc(II) complexes of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin (HL1 and HL2, respectively) were synthesized and characterized, being the crystal structures of HL1, HL2 and [Ni(L1)2] · 2CHCl3 elucidated by X-ray diffraction techniques. The in vitro antimicrobial activity of all these compounds was tested against several bacteria and fungi. HL1and its complexes exhibited a strong inhibition of the growth of Haemophilus influenzae (MIC 0.15–1.50 μg/mL) and good antibacterial properties towards Bacillus subtilis (MIC 3–25 μg/mL). The minimal inhibitory concentration (MIC) was defined as the lowest concentration of compound inhibiting the growth of each strain. The antibacterial effectiveness was confirmed against a number of Gram positive bacteria, including methicillin-resistant Staphylococcus aureus. Yeasts and moulds showed a low susceptibility, except the dermatophyte mould Epidermophyton floccosum that is inhibited at concentrations ranging from 6 to 50 μg/mL. In general, the antimicrobial activity of the thiophene derivatives was greater than that of the isonicotinic analogues.

Complex of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin. A study of their antimicrobial activity / RODRIGUEZ ARGUELLES M., C; MOSQUERA VAZQUEZ, S; TOURON TOUCEDA, P; SANMARTIN MATALOBOS, J; GARCIA DEIBE A., M; Ferrari, Marisa; Pelosi, Giorgio; Pelizzi, Corrado; Zani, Franca. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 101:(2007), pp. 138-147. [10.1016/j.jinorgbio.2006.09.004]

Complex of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin. A study of their antimicrobial activity

FERRARI, Marisa;PELOSI, Giorgio;PELIZZI, CORRADO;ZANI, Franca
2007

Abstract

Cobalt(II), nickel(II), copper(II) and zinc(II) complexes of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin (HL1 and HL2, respectively) were synthesized and characterized, being the crystal structures of HL1, HL2 and [Ni(L1)2] · 2CHCl3 elucidated by X-ray diffraction techniques. The in vitro antimicrobial activity of all these compounds was tested against several bacteria and fungi. HL1and its complexes exhibited a strong inhibition of the growth of Haemophilus influenzae (MIC 0.15–1.50 μg/mL) and good antibacterial properties towards Bacillus subtilis (MIC 3–25 μg/mL). The minimal inhibitory concentration (MIC) was defined as the lowest concentration of compound inhibiting the growth of each strain. The antibacterial effectiveness was confirmed against a number of Gram positive bacteria, including methicillin-resistant Staphylococcus aureus. Yeasts and moulds showed a low susceptibility, except the dermatophyte mould Epidermophyton floccosum that is inhibited at concentrations ranging from 6 to 50 μg/mL. In general, the antimicrobial activity of the thiophene derivatives was greater than that of the isonicotinic analogues.
Complex of 2-thiophenecarbonyl and isonicotinoyl hydrazones of 3-(N-methyl)isatin. A study of their antimicrobial activity / RODRIGUEZ ARGUELLES M., C; MOSQUERA VAZQUEZ, S; TOURON TOUCEDA, P; SANMARTIN MATALOBOS, J; GARCIA DEIBE A., M; Ferrari, Marisa; Pelosi, Giorgio; Pelizzi, Corrado; Zani, Franca. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 101:(2007), pp. 138-147. [10.1016/j.jinorgbio.2006.09.004]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2293398
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