Downstream A₃ receptor signalling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A₃ receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated protein kinase (MAPK/ERK) kinase (MEK)/mitogen-activated protein kinase (MAPK) pathways have central roles in the regulation of cell survival and proliferation. The crosstalk between these two pathways has also been investigated. The focus of this review centres on downstream mediators of A₃ adenosine receptor signalling.
Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor / Merighi, S.; Benini, A.; Mirandola, Prisco; Gessi, S.; Varani, K.; Leung, E.; Maclennan, S.; Baraldi, P. G.; Borea, P. A.. - In: PURINERGIC SIGNALLING. - ISSN 1573-9538. - 2:(2006), pp. 627-632. [10.1007/s11302-006-9020-4]
Modulation of the Akt/Ras/Raf/MEK/ERK pathway by A(3) adenosine receptor.
MIRANDOLA, Prisco;
2006-01-01
Abstract
Downstream A₃ receptor signalling plays an important role in the regulation of cell death and proliferation. Therefore, it is important to determine the molecular pathways involved through A₃ receptor stimulation. The phosphatidylinositide-3-OH kinase (PI3K)/Akt and the Raf/mitogen-activated protein kinase (MAPK/ERK) kinase (MEK)/mitogen-activated protein kinase (MAPK) pathways have central roles in the regulation of cell survival and proliferation. The crosstalk between these two pathways has also been investigated. The focus of this review centres on downstream mediators of A₃ adenosine receptor signalling.| File | Dimensione | Formato | |
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