Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.
Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription / Tavenet, A; Suleau, A; Dubreuil, G; Ferrari, R; Ducrot, C; Michaut, M; Aude, Jc; Dieci, Giorgio; Lefebvre, O; Conesa, C; Acker, J.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 106:(2009), pp. 14265-14270. [10.1073/pnas.0900162106]
Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription.
FERRARI R;DIECI, Giorgio;
2009-01-01
Abstract
Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.| File | Dimensione | Formato | |
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