A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNav1.2 sodium channel currents. One member of this series (4) exhibited profound inhibition of Nav1.2 currents, emerging as a promising lead compound for further structure–activity relationship studies for the development of novel sodium channel blockers.
2,4(5)-Diarylimidazoles: Synthesis and Biological Evaluation of a New Class of Sodium Channel Blockers against hNav1.2 / RIVARA M.; BAHETI A.R.; FANTINI M.; COCCONCELLI G.; GHIRON C.; KALMAR C.L.; SINGH N.; MERRICK E.C.; PATEL M.K.; ZULIANI V.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 18(2008), pp. 5454-5456. [10.1016/j.jmcl.2008.09.036]