A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNav1.2 sodium channel currents. One member of this series (4) exhibited profound inhibition of Nav1.2 currents, emerging as a promising lead compound for further structure–activity relationship studies for the development of novel sodium channel blockers.
2,4(5)-Diarylimidazoles: Synthesis and Biological Evaluation of a New Class of Sodium Channel Blockers against hNav1.2 / Rivara, M., Baheti, A.R., Fantini, M., Cocconcelli, G., Ghiron, C., Kalmar, C.L., Singh, N., Merrick, E.C., Patel, M.K., Zuliani, V.. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 18:(2008), pp. 5454-5456. [10.1016/j.jmcl.2008.09.036]
2,4(5)-Diarylimidazoles: Synthesis and Biological Evaluation of a New Class of Sodium Channel Blockers against hNav1.2
RIVARA, Mirko;ZULIANI, Valentina
2008-01-01
Abstract
A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNav1.2 sodium channel currents. One member of this series (4) exhibited profound inhibition of Nav1.2 currents, emerging as a promising lead compound for further structure–activity relationship studies for the development of novel sodium channel blockers.| File | Dimensione | Formato | |
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