A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNav1.2 sodium channel currents. One member of this series (4) exhibited profound inhibition of Nav1.2 currents, emerging as a promising lead compound for further structure–activity relationship studies for the development of novel sodium channel blockers.
2,4(5)-Diarylimidazoles: Synthesis and Biological Evaluation of a New Class of Sodium Channel Blockers against hNav1.2 / Rivara, Mirko; Baheti, A. R.; Fantini, M.; Cocconcelli, G.; Ghiron, C.; Kalmar, C. L.; Singh, N.; Merrick, E. C.; Patel, M. K.; Zuliani, Valentina. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 18:(2008), pp. 5454-5456. [10.1016/j.jmcl.2008.09.036]
2,4(5)-Diarylimidazoles: Synthesis and Biological Evaluation of a New Class of Sodium Channel Blockers against hNav1.2
RIVARA, Mirko;ZULIANI, Valentina
2008-01-01
Abstract
A small family of novel 2,4(5)-diarylimidazoles were prepared through a simple and efficient synthesis and evaluated as potential inhibitors of hNav1.2 sodium channel currents. One member of this series (4) exhibited profound inhibition of Nav1.2 currents, emerging as a promising lead compound for further structure–activity relationship studies for the development of novel sodium channel blockers.| File | Dimensione | Formato | |
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