Physical properties (roughness, gloss, mechanical, surface topography and adhesive) of a bioadhesive film for the transdermal delivery of drugs and its interactions with a skin model surface were studied. Roughness is a measurement of the small-scale variations in the height of a physical surface. No significant differences in Ra between the "x" and "y" dimensions for both the skin model and patch were detected, due to uniformity in their production. Scanning electron microscope pictures showed small particles projected from the film. Those particles resulted in increasing roughness and surface area. For the patch, gloss values measured at 20° were 6.0 ± 0.9 and at 60°, 32.2 ± 2.2 gloss units, respectively, indicating a semi-gloss material. Concerning the mechanical properties, the tensile strength of the film resulted four- to sevenfold greater than the peel force from the model skin used, indicating the suitability of the film for skin application. The adhesion to skin model depended on the amount of water used for film application and on the elapsed time between film application and removal. Finally, the model skin that was invented by Charkoudian can be used as an alternative to costly and highly variable human skin substrates since it possesses human topography.

Physical characterization of a new skin bioadhesive film / Nussinovitch, A.; Gal, A.; Padula, Cristina; Santi, Patrizia. - In: AAPS PHARMSCITECH. - ISSN 1530-9932. - 9:2(2008), pp. 458-463. [10.1208/s12249-008-9061-9]

Physical characterization of a new skin bioadhesive film

PADULA, Cristina;SANTI, Patrizia
2008-01-01

Abstract

Physical properties (roughness, gloss, mechanical, surface topography and adhesive) of a bioadhesive film for the transdermal delivery of drugs and its interactions with a skin model surface were studied. Roughness is a measurement of the small-scale variations in the height of a physical surface. No significant differences in Ra between the "x" and "y" dimensions for both the skin model and patch were detected, due to uniformity in their production. Scanning electron microscope pictures showed small particles projected from the film. Those particles resulted in increasing roughness and surface area. For the patch, gloss values measured at 20° were 6.0 ± 0.9 and at 60°, 32.2 ± 2.2 gloss units, respectively, indicating a semi-gloss material. Concerning the mechanical properties, the tensile strength of the film resulted four- to sevenfold greater than the peel force from the model skin used, indicating the suitability of the film for skin application. The adhesion to skin model depended on the amount of water used for film application and on the elapsed time between film application and removal. Finally, the model skin that was invented by Charkoudian can be used as an alternative to costly and highly variable human skin substrates since it possesses human topography.
2008
Physical characterization of a new skin bioadhesive film / Nussinovitch, A.; Gal, A.; Padula, Cristina; Santi, Patrizia. - In: AAPS PHARMSCITECH. - ISSN 1530-9932. - 9:2(2008), pp. 458-463. [10.1208/s12249-008-9061-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1859438
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