Investigated for applications as highly biocompatible drug carriers. A detailed understanding of particle–solvent interactions is of key importance in order to tailor their characteristics for delivering drugs with specific chemical properties. Here we report results of a quasielastic neutron scattering (QENS) investigation on lecithin Nano- and microparticles composed of saccharide and lipid systems are extensively /chitosan nanoparticles prepared by autoassembling the two components in an aqueous solution. The measurements were performed at room temperature on lyophilized and H2O hydrated nanoparticles (h = 0.47 w H2O/w hydrated sample). In the latter, hydration water is mostly enclosed inside the nanoparticles; its dynamics is similar to that of bulk water but with a significant decrease in diffusivity. The scattering from the nanoparticles can be described by a simple model of confined diffusion. In the lyophilized state only hydrogens belonging to the polar heads are seen as mobile within the experimental time-window. In the hydrated sample the diffusive dynamics involves also a significant part of the hydrogens in the lipid tails.

Dynamics of lipid–saccharide nanoparticles by quasielastic neutron scattering / DI BARI, Maria; Gerelli, Yuri; Sonvico, Fabio; Deriu, Antonio; Cavatorta, Fabrizio; Albanese, Gian Franco; Colombo, Paolo; FERNANDEZ ALONSO, F.. - In: CHEMICAL PHYSICS. - ISSN 0301-0104. - 345:2-3(2008), pp. 239-244. [10.1016/j.chemphys.2007.08.006]

Dynamics of lipid–saccharide nanoparticles by quasielastic neutron scattering

DI BARI, Maria;GERELLI, Yuri;SONVICO, Fabio;DERIU, Antonio;CAVATORTA, Fabrizio;ALBANESE, Gian Franco;COLOMBO, Paolo;
2008

Abstract

Investigated for applications as highly biocompatible drug carriers. A detailed understanding of particle–solvent interactions is of key importance in order to tailor their characteristics for delivering drugs with specific chemical properties. Here we report results of a quasielastic neutron scattering (QENS) investigation on lecithin Nano- and microparticles composed of saccharide and lipid systems are extensively /chitosan nanoparticles prepared by autoassembling the two components in an aqueous solution. The measurements were performed at room temperature on lyophilized and H2O hydrated nanoparticles (h = 0.47 w H2O/w hydrated sample). In the latter, hydration water is mostly enclosed inside the nanoparticles; its dynamics is similar to that of bulk water but with a significant decrease in diffusivity. The scattering from the nanoparticles can be described by a simple model of confined diffusion. In the lyophilized state only hydrogens belonging to the polar heads are seen as mobile within the experimental time-window. In the hydrated sample the diffusive dynamics involves also a significant part of the hydrogens in the lipid tails.
Dynamics of lipid–saccharide nanoparticles by quasielastic neutron scattering / DI BARI, Maria; Gerelli, Yuri; Sonvico, Fabio; Deriu, Antonio; Cavatorta, Fabrizio; Albanese, Gian Franco; Colombo, Paolo; FERNANDEZ ALONSO, F.. - In: CHEMICAL PHYSICS. - ISSN 0301-0104. - 345:2-3(2008), pp. 239-244. [10.1016/j.chemphys.2007.08.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1850024
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