Femtomolar single-base mismatch discrimination:a nanoparticle-enhanced surface plasmon resonance imaging method for ultrasensitive detection of the selective hybridization between a peptide nucleic acid (PNA) oligomer and its complementary single-stranded DNA target is described. The method allows a 1 fm sensitivity in single-base mismatch discrimination with only 150 zeptomoles of the target molecules.
Ultrasensitive Detection of DNA by PNA and Nanoparticle-Enhanced Surface Plasmon Resonance Imaging / R., D'Agata; Corradini, Roberto; G., Grasso; Marchelli, Rosangela; G., Spoto. - In: CHEMBIOCHEM. - ISSN 1439-4227. - 9:(2008), pp. 2067-2070. [10.1002/cbic.200800310]
Ultrasensitive Detection of DNA by PNA and Nanoparticle-Enhanced Surface Plasmon Resonance Imaging
CORRADINI, Roberto;MARCHELLI, Rosangela;
2008-01-01
Abstract
Femtomolar single-base mismatch discrimination:a nanoparticle-enhanced surface plasmon resonance imaging method for ultrasensitive detection of the selective hybridization between a peptide nucleic acid (PNA) oligomer and its complementary single-stranded DNA target is described. The method allows a 1 fm sensitivity in single-base mismatch discrimination with only 150 zeptomoles of the target molecules.| File | Dimensione | Formato | |
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