Fine chemicals are complex and multifunctional molecules, often characterized by low volatility and limited thermal stability, whose manufacture generally is based on multistep synthesis performed in the liquid phase and frequently involving protection‐deprotection steps. The use of blocking functions in organic synthesis, developed for nearly 100 years, makes more complex the entire synthetic plan since it requires at least two additional steps. At the same time, environmental and economic considerations have created interest, in both academic and industrial research, in design‐ ing synthetic procedures that are clean, selective, high‐ yielding, and manipulatively easy.
Protection (and Deprotection) of Functional Groups in Organic Synthesis by Heterogeneous Catalysis / Sartori, Giovanni; R., Ballini; Bigi, Franca; G., Bosica; Maggi, Raimondo; P., Righi. - In: CHEMICAL REVIEWS. - ISSN 0009-2665. - 104(2004), pp. 199-250. [10.1021/cr0200769]