Human herpesvirus 6 (HHV-6) presents a perfect tandem array of human telomeric repeats (TRS) at both identical direct repeats (DR). Several researchers have reported a different TRS copy number by sequence analysis of HHV-6 DR's cloned fragments so it has been hypothesized that number of TRS is unstable. By PCR we show that the TRS copy number of U1102 HHV-6 variant A strains is stable during viral cultivation in cell lines and each HHV-6 variant A strain, detected in pathologic specimens, is characterized by a specific TRS copy number
PCR analysis of human telomeric repeats present on HHV-6A viral strains / Mirandola, Prisco; Ravaioli, T.; Cassai, E.. - In: VIRUS GENES. - ISSN 0920-8569. - 15:(1997), pp. 29-32.
PCR analysis of human telomeric repeats present on HHV-6A viral strains
MIRANDOLA, Prisco;
1997-01-01
Abstract
Human herpesvirus 6 (HHV-6) presents a perfect tandem array of human telomeric repeats (TRS) at both identical direct repeats (DR). Several researchers have reported a different TRS copy number by sequence analysis of HHV-6 DR's cloned fragments so it has been hypothesized that number of TRS is unstable. By PCR we show that the TRS copy number of U1102 HHV-6 variant A strains is stable during viral cultivation in cell lines and each HHV-6 variant A strain, detected in pathologic specimens, is characterized by a specific TRS copy number| File | Dimensione | Formato | |
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