The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his article ‘‘IL-6: A Cytokine for Gerontologists,’’ indicated IL-6 as one of the main signaling pathways modulating the complex relationship between aging and chronic morbidity. Over the last 12 years, our understanding of the role of IL-6 in human physiology and pathology has substantially grown, although some of the questions originally posed by Ershler are still debated. In this review, we will focus on IL-6 structure, IL-6 signaling, and trans signaling pathways, and the role of IL-6 in geriatric syndromes and chronic disease. In the final section of this review, we dissect the critical elements of the IL-6 signaling pathway and point out targets for intervention that are targeted by emerging drugs, some still on the horizon and others already being tested in clinical trials

Interleukin-6 in aging and chronic disease: a magnificent pathway / Maggio, Marcello Giuseppe; Guralnik, Jm; Longo, Dl; Ferrucci, L.. - In: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. - ISSN 1079-5006. - 61(6):(2006), pp. 575-584.

Interleukin-6 in aging and chronic disease: a magnificent pathway.

MAGGIO, Marcello Giuseppe;
2006-01-01

Abstract

The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his article ‘‘IL-6: A Cytokine for Gerontologists,’’ indicated IL-6 as one of the main signaling pathways modulating the complex relationship between aging and chronic morbidity. Over the last 12 years, our understanding of the role of IL-6 in human physiology and pathology has substantially grown, although some of the questions originally posed by Ershler are still debated. In this review, we will focus on IL-6 structure, IL-6 signaling, and trans signaling pathways, and the role of IL-6 in geriatric syndromes and chronic disease. In the final section of this review, we dissect the critical elements of the IL-6 signaling pathway and point out targets for intervention that are targeted by emerging drugs, some still on the horizon and others already being tested in clinical trials
2006
Interleukin-6 in aging and chronic disease: a magnificent pathway / Maggio, Marcello Giuseppe; Guralnik, Jm; Longo, Dl; Ferrucci, L.. - In: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. - ISSN 1079-5006. - 61(6):(2006), pp. 575-584.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1631799
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